A highly selective fluorescent probe for the detection of hypochlorous acid in tap water and living cells

作者：Wang, Xiao; Zhou, Yanmei^*; Xu, Chenggong; Song, Haohan; Li, Li; Zhang, Junli; Guo, Meixia

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2018, 203: 415-420.

DOI：10.1016/j.saa.2018.06.012

• Hypochlorous acid
• Fluorescent probe
• Test paper
• Living cells

A turn-on fluorescent probe (DAME) for sensing hypochlorous acid (HCIO) with excellent selectivity was presented. The fluorescent probe was composed of coumarin derivative as the fluorophore and dimethylcarbamothioic chloride group with a sulfide moiety as modulator. Additionally, the sulfide moiety would be oxidized by HCIO, and then free dye of coumarin derivate was released and exhibited significant fluorescence. In addition, the probe could respond to HCIO in solutions within 60 s and the limit of detection was down to 34.75 nM. Moreover, the probe was used for the detection of HCIO in tap water through the home-made test paper. And confocal images confirmed that probe DAME could be used for recognizing HCIO in living cells.

• 出版日期2018-10-5
• 单位河南大学