科研之友
微信
新浪微博
Facebook
分享链接
摘要
The article describes unusual [5+1]-cyclocondensations of dimethyl acetylenedicarboxylate (DMAD), in which this reagent uncharacteristically acts as a 1,1-biselelectrophilic agent. Reactions of DMAD with 1,5-bisnucleophilic 3-(2-aminophenyl)-6-R-1-1,2,4-triazin-5(2H)-ones yielded triazinoquinazoline-derived diesters. The latter was shown to react with nucleophiles: hydrazine cleaved the pyrimidine ring of the diesters to give anilines, while ester hydrolysis furnished corresponding carboxylic acids.
- 出版日期2017-5
