An Efficient and Facile Synthesis of Pyrimidine and Quinazoline Derivatives via One-Pot Three-Component Reaction under Solvent-Free Conditions

作者:Rong Liangce*; Han Hongxia; Wang Haiying; Jiang Hong; Tu Shuajiang; Shi Daqing
来源:Journal of Heterocyclic Chemistry, 2009, 46(2): 152-157.
DOI:10.1002/jhet.43

摘要

An efficient and convenient method for the preparation of pyrimidine and quinazoline derivatives by the one-pot reaction of aromatic aldehydes, cyclic ketones and guanidine carbonate, in the presence of sodium hydroxide under solvent-free condition was reported. This method has the advantages of excellent yields, mild reaction conditions, easy work-up, and being environmentally friendly over the existing procedures.