科研之友
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摘要
Ferrocenyl derivative 2, which possesses a bipbenyl unit, was prepared by nickel (0) -mediated homocoupling of a chiral ferrocenyloxazoline. Compound 2 exists as an equilibrium mixture of two diastereomers, in a ratio dependent on temperature and solvent, due to the partially hindered rotation around biaryl bond. Upon complexation with Cu(I) or Zn(II), complete fixation of the stereogenic axis was obtained and a single stable atropoisomer was formed, whose absolute configuration was assigned on the basis of its NOESY spectrum. The 2-Cu(I) complex was used as catalyst in the cyclopropartation of styrene. Chirality 17:233-236, 2005.
- 出版日期2005-5-5
