One-pot multicomponent synthesis of diazepine derivatives using terminal alkynes in the presence of silica-supported superparamagnetic iron oxide nanoparticles

作者：Maleki Ali^*

来源：Tetrahedron Letters, 2013, 54(16): 2055-2059.

DOI：10.1016/j.tetlet.2013.01.123

• Superparamagnetic
• Nanocatalyst
• Multicomponent reaction
• Fe3O4/SiO2 nanoparticles
• Diazepine

A new, efficient, one-pot multicomponent reaction for the synthesis of diazepine derivatives in excellent yields is described. The reactions of various 1,2-diamines, terminal alkynes, and an isocyanide take place in the presence of a catalytic amount of magnetically recoverable silica-supported superparamagnetic Fe3O4 nanoparticles in ethanol (as a green reaction medium) at ambient temperature.

• 出版日期2013-4-17