Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis

作者：Rondon Carmen^*; Campo Paloma; Herrera Rocio; Blanca Lopez Natalia; Melendez Lidia; Canto Gabriela; Torres Maria J; Blanca Miguel

来源：Journal of Allergy and Clinical Immunology, 2011, 128(6): 1192-1197.

DOI：10.1016/j.jaci.2011.06.012

• Acoustic rhinometry
• local allergic rhinitis
• nasal allergen provocation test
• visual analog scale

Background: Patients previously given a diagnosis of nonallergic rhinitis (NAR) might have a new form of local allergic rhinitis (LAR) with local production of specific IgE antibodies and a positive response to a nasal allergen provocation test (NAPT).
Objective: We evaluated an NAPT protocol using multiple aeroallergens (NAPT-M) for the detection of polysensitization to several aeroallergens in patients with LAR.
Methods: NAPT-Ms with 2 different panels of aeroallergens for patients with perennial and seasonal rhinitis were performed in 25 patients with LAR and 25 patients with NAR whose disease was diagnosed by means of NAPTs 1 year earlier. The response to nasal challenge was evaluated based on subjective (nasal-ocular symptoms) and objective (acoustic rhinometry) parameters. Nasal levels of tryptase and eosinophil cationic protein were determined by means of immunoassay at baseline, 15 minutes, and 1, 2, and 24 hours after challenge.
Results: NAPT-Ms showed 100% concordance with the gold standard of NAPTs with a single aeroallergen. No false-positive or false-negative responses were detected. The use of NAPT-Ms achieved 75% reduction in the total number of visits required for final diagnosis in the NAR group (from 168 to 42 visits) and a 55% reduction in the LAR group (from 144 to 65 visits) compared with NAPTs with a single aeroallergen.
Conclusions: These results demonstrate that clinically relevant polysensitization to aeroallergens in patients with LAR occurred and that the NAPT-M is a useful, specific, sensitive, reproducible, and less time-consuming in vivo diagnostic test for the screening of patients with LAR. (J Allergy Clin Immunol 2011;128:1192-7.)

• 出版日期2011-12