科研之友
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摘要
A protocol for the chemoselective synthesis of the fungal metabolite fungerin has been developed. First the required N-methyl alpha-aminoketone was generated starting from sarcosine, propiolic acid, and prenyl bromide. Marckwald thioimidazole cyclization and subsequent sulfur removal delivered the target fungerin as well as an analogue, respectively, displaying defined substitution patterns.
- 出版日期2017-2
