Actin: From structural plasticity to functional diversity

作者:Schoenenberger Cora Ann; Mannherz Hans Georg; Jockusch Brigitte M*
来源:European Journal of Cell Biology, 2011, 90(10): 797-804.
DOI:10.1016/j.ejcb.2011.05.002

摘要

This article addresses the multiple activities of actin. Starting out with the history of actin's discovery, purification and structure, it emphasizes the close relation between structure and function. In this context, we also point to unconventional actin conformations. Their existence in living cells is not yet well documented, however, they seem to play a special role in the supramolecular patterning that underlies some of the physiological functions of actin. Conceivably, such conformations may contribute to actin's diverse activities in the nucleus that are poorly understood so far.

  • 出版日期2011-10