All the commercially available adhesion barriers have the same effect on adhesion prophylaxis?; A comparison of barrier agents using a newly developed, severe intra-abdominal adhesion model

作者：Hwang Hyo Jun; An Min Sung; Ha Tae Kwun; Kim Kwang Hee; Kim Tae Hyeon; Choi Chang Soo; Hong Kwan Hee; Jung Soo Jin; Kim Sun Hee; Rho Kuk Hwan; Bae Ki Beom^*

来源：International Journal of Colorectal Disease, Clinical and Molecular Gastroenterology and Surgery, 2013, 28(8): 1117-1125.

DOI：10.1007/s00384-013-1679-8

• Adhesion prevention
• Adhesion barrier
• Seprafilm (R)
• Adept (R)
• Guardix (R)

Various types of adhesion barriers are widely used to prevent intra-abdominal adhesion. However, few studies have compared the efficacy of adhesion barriers using the same animal model. The aim of this study was to compare the anti-adhesive effects of various barrier agents using a newly developed, severe adhesion model. %26lt;br%26gt;A severe adhesion model was established by excision of a 1-cm(2) intra-abdominal wall and application of cyanoacrylate in rat. Eighty male Sprague-Dawley rats (10 weeks old; 370 +/- 50 g) were divided randomly into four groups (n = 20 each): the untreated control group, G-group using a hyaluronic acid and sodium carboxymethyl cellulose gel (Guardix-solA (R)), A-group using 4 % icodextrin (AdeptA (R)), and S-group using a hyaluronate-carboxymethyl cellulose membrane (SeprafilmA (R)). The effect of each adhesion barrier was evaluated by means of the extent and severity of adhesion, difficulty of adhesiolysis scoring systems, and microscopic grade of fibrosis. %26lt;br%26gt;The G-group showed no difference in adhesion score and fibrosis, the A-group demonstrated only a significantly lower fibrosis, and the S-group exhibited a significantly lower adhesion score and lower fibrosis compared with the control group. The S-group had a significantly lower adhesion score and reduced fibrosis compared with the G-group; however, no significant difference in adhesion score and fibrosis was noted with the A-group. %26lt;br%26gt;The membranous barrier SeprafilmA (R) may be effective in the prevention of adhesion in the condition of peritoneal injury combined with foreign material. AdeptA (R) showed a tendency of decreasing the severity of adhesion and was effective in the prevention of fibrosis.

• 出版日期2013-8