SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

作者：Unoki Hiroyuki; Takahashi Atsushi; Kawaguchi Takahisa; Hara Kazuo; Horikoshi Momoko; Andersen Gitte; Ng Daniel P K; Holmkvist Johan; Borch Johnsen Knut; Jorgensen Torben; Sandbaek Annelli; Lauritzen Torsten; Hansen Torben; Nurbaya Siti; Tsunoda Tatsuhiko; Kubo Michiaki; Babazono Tetsuya; Hirose Hiroshi; Hayashi Matsuhiko; Iwamoto Yasuhiko; Kashiwagi Atsunori; Kaku Kohei; Kawamori Ryuzo; Tai E Shyong; Pedersen Oluf; Kamatani Naoyuki; Kadowaki Takashi

来源：Nature Genetics, 2008, 40(9): 1098-1102.

DOI：10.1038/ng.208

We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 x 10(-12); OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 x 10(-9); OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 x 10(-13); OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36).

• 出版日期2008-9
• 单位河北医科大学