Asymmetric synthesis of 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxides catalyzed by scandium(III)-inda-Pybox

作者：Du, Peng; Zhou, Haifeng^*; Sui, Yuebo; Liu, Qixing; Zou, Kun

来源：Tetrahedron, 2016, 72(12): 1573-1578.

DOI：10.1016/j.tet.2016.02.009

• Asymmetric synthesis
• Scandium triflate
• Chiral aminals
• Pybox
• Benzothiadiazine

Asymmetric synthesis of 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxides (DHBDs) was realized using readily available scandium(III)-inda-Pybox as the catalyst. It represents the first example focusing on systematic study of asymmetric synthesis of DHBDs, and a series of enantioselective 3-alkyl, or 3-aryl DHBDs were obtained with up to 93% ee.

• 出版日期2016-3-24
• 单位三峡大学