Acceleration of the Eschenmoser coupling reaction by sonication: efficient synthesis of enaminones

作者:Koduri Naga Durgarao*; Hileman Bethany; Cox Justin D; Scott Halee; Phuong Hoang; Robbins Alexa; Bowers Kyle; Tsebaot Lemma; Miao Kun; Castaneda Maria; Coffin Michael; Wei Guan; Claridge Tim D W; Roberts Kenneth P; Hussaini Syed Raziullah
来源:RSC Advances, 2013, 3(1): 181-188.
DOI:10.1039/c2ra22033d

摘要

Enaminones are commonly prepared by the Eschenmoser coupling reaction. The duration of the reaction is often long. Here, we describe how sonication can accelerate this reaction. The reaction conditions provide an efficient method for the coupling of primary, secondary and tertiary thioamides with alpha-bromocarbonyl compounds.

  • 出版日期2013

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