Non-motor symptoms in patients with hereditary spastic paraplegia caused by SPG4 mutations

作者：Servelhere K R; Faber I; Saute J A M; Moscovich M; D'Abreu A; Jardim L B; Teive H A G; Lopes Cendes I; Franca M C Jr^*

来源：European Journal of Neurology, 2016, 23(2): 408-411.

DOI：10.1111/ene.12839

• depression
• fatigue
• non-motor symptoms
• pain
• spastic paraplegia
• SPG4

Background and purposeNon-motor manifestations are frequently overlooked in degenerative disorders and little is known about their frequency and clinical relevance in SPG4 hereditary spastic paraplegia (SPG4-HSP).
MethodsThirty patients with SPG4-HSP and 30 healthy controls answeredthe Modified Fatigue Impact Scale, Epworth Sleepiness Scale, Brief Pain Inventory and Beck Depression Inventory. Student's t test wasused to compare groups and linear regression was used to assess correlations.
ResultsPatients had higher fatigue scores than controls (31.016.5 vs. 14.5 +/- 16.0, P=0.002) as well as pain (3.4 +/- 2.7 vs. 1.0 +/- 1.6, P=0.001) and depression (12.7 +/- 8.9 vs. 4.4 +/- 3.8, P<0.001, respectively). Fatigue was associated with depression and possibly with disease severity (P=0.008 and 0.07, respectively).
ConclusionsFatigue, pain and depression are frequent and often severe manifestations in patients with SPG4-HSP.

• 出版日期2016-2