An enantiocontrolled entry to the tricyclic polar segment of (+)-fusarisetin A

作者：Kohyama Aki; Kanoh Naoki; Kwon Eunsang; Iwabuchi Yoshiharu

来源：Tetrahedron Letters, 2016, 57(5): 517-519.

DOI：10.1016/j.tetlet.2015.12.049

• Fusarisetin A
• Yamamoto asymmetric epoxidation
• Epoxide ring opening
• Oxidative lactonization

The tricyclic polar segment of fusarisetin A, designed for preparing analogues for structure-activity relationship studies of the aliphatic segment thereof, has been constructed in an enantiocontrolled manner, featuring the Yamamoto asymmetric epoxidation of a homoallylic alcohol, C3-selective ring-opening of a 3,4-epoxy alcohol, stereocontrolled merger of a gamma-lactone with Garner's counterpart, and ruthenium catalyzed ring-closing metathesis.

• 出版日期2016-2-3