mu-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies

作者：Chetana P R^*; Rao Ramakrishna; Lahiri Debojyoti; Policegoudra R S; Sankolli Ravish; Aradhya M S

来源：Polyhedron, 2014, 68: 172-179.

DOI：10.1016/j.poly.2013.10.025

• Binuclear
• Copper (II)
• Oxpn
• DNA interaction
• Antibacterial

Four binuclear copper (II) complexes [Cu(oxpn)Cu(B)](2+) (2-5) bridged by N, N%26apos;-bis[3-(methylamino) propyl] oxamide (oxpn), where, B is N, N-donor heterocyclic bases (viz. 2,2%26apos;-bipyridine (bpy, 2), 1,10-phenathroline (phen, 3), dipyrido[3,2-d:2%26apos;,3%26apos;-f]quinoxaline (dpq, 4) and dipyrido[3,2-a:2%26apos;,3%26apos;-c]phenazine (dppz, 5) are synthesized, characterized by different spectroscopic and single crystal X-ray data technique. The phen (3) and dpq (4) complexes were structurally characterized by X-ray data analysis. Their DNA binding, oxidative cleavage and antibactirial activities were studied. The dpq (4) and dppz (5) complexes are avid binders to the Calf thymus DNA (CT-DNA). The phen (3), dpq (4) and dppz (5) complexes show efficient oxidative cleavage of supercoiled DNA (SC DNA) through hydroxyl radical ((OH)-O-center dot) pathway in the presence of Mercaptopropionic acid (MPA).

• 出版日期2014-1-28