Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense

作者：Lee Chia Lin; Hwang Tsong Long; Peng Chieh Yu; Chen Chao Jung; Kuo Chao Lin; Chang Wen Yi; Wu Yang Chang^*

来源：Natural Product Communications, 2015, 10(2): 345-348.

DOI：10.1177/1934578x1501000235

• Solanum macaonense
• Solanaceae
• Anti-inflammation
• Cytotoxicity

One new cerebroside, macaocerebroside A (1), and 15 known compounds (2-16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2-5) were active against superoxide anion generation with IC50 values of 3.3-4.8 mu M; especially, 3 inhibited elastase release with an IC50 value of 4.0 mu M. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC50 value of 4.0 mu M. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC50 values of 34.6, 41.3, and 31.8 mu M, respectively.

• 出版日期2015-2
• 单位长春大学; 中国医科大学