Direct Amide Synthesis from Either Alcohols or Aldehydes with Amines: Activity of Ru(II) Hydride and Ru(0) Complexes

作者：Muthaiah, Senthilkumar; Ghosh, Subhash Chandra; Jee, Joo-Eun; Chen, Cheng; Zhang, Jian; Hong, Soon Hyeok^*

来源：Journal of Organic Chemistry, 2010, 75(9): 3002-3006.

DOI：10.1021/jo100254g

• CATALYZED N-ALKYLATION
• BOND FORMATION
• OXIDATIVE TRANSFORMATION
• BORROWING HYDROGEN
• RUTHENIUM CATALYST
• SECONDARY ALCOHOLS
• COUPLING REAGENTS
• TERTIARY-AMINES
• MILD AMIDATION
• AMINATION

An in situ generated catalyst from readily available RuH(2)(PPh(3))(4), an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile was developed. The catalyst showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines. When a mixture of an alcohol and an aldehyde was reacted with an amine, both of the corresponding amides were obtained with good yields. Homogeneous Ru(0) complexes such as eta(4)-1,5-cyclooctadiene)(eta(6)-1,3,5-cyclooetatriene)-ruthenium [Ru(cod)(cot)] and Ru(3)(CO)(12) were also active in the amidation of an alcohol or an aldehyde with the help of an in situ generated NHC ligand.

• 出版日期2010-5-7
• 单位南阳理工学院