A Mild and Efficient Three-Component Synthesis of Secondary and Tertiary Homoallylic Hydrazides

作者：Lee Bum Seok; Jang Doo Ok^*

来源：European Journal of Organic Chemistry, 2013, 2013(15): 3123-3130.

DOI：10.1002/ejoc.201201757

• Multicomponent reactions
• Allylation
• Aldehydes
• Ketones
• Chemoselectivity
• Hydrazides

A three-component reaction that involved a carbonyl compound, benzoylhydrazine, allyl bromide, and indium in the presence of readily available Zn(ClO4)(2)center dot 6H(2)O was developed for the syntheses of secondary and tertiary homoallylic hydrazides. Excellent chemoselectivities and diastereoselectivies were observed. Aldehydes as well as acyclic and cyclic ketones were well-suited to the reaction conditions and provided secondary and tertiary homoallylic hydrazides in excellent yields.

• 出版日期2013-5