A new label-free electrochemical immunosensor based on dendritic core-shell AuPd@Au nanocrystals for highly sensitive detection of prostate specific antigen

作者：Wang, Rui; Liu, Wei-Dong; Wang, Ai-Jun^*; Xue, Yadong; Wu, Liang; Feng, Jiu-Ju^*

来源：Biosensors and Bioelectronics, 2018, 99: 458-463.

DOI：10.1016/j.bios.2017.08.010

• Label-free immunosensor
• Xanthine
• Core-shell nanocrystals
• Prostate specific antigen

Herein, bimetallic dendritic core-shell AuPd@Au nanocrystals (AuPd@Au NCs) were prepared by a simple one pot aqueous method using xanthine as a green growth-directing agent. By virtue of the enhanced peak currents in the H2O2 reduction catalyzed by AuPd@Au NCs, a label-free immunosensor was constructed for the detection of prostate specific antigen (PSA). The immunosensor exhibited significantly improved analytical performance for the assay of PSA with wide linear range of 0.1-50 ng mL(-1) and low detection limit of 0.078 ng mL(-1) (S/N = 3), coupled with the improved stability, reproducibility and selectivity. It provides a promising platform for clinical research and diagnosis.

• 出版日期2018-1-15
• 单位浙江师范大学