Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome

作者：Kurano Makoto; Kano Kuniyuki; Dohi Tomotaka; Matsumoto Hirotaka; Igarashi Koji; Nishikawa Masako; Ohkawa Ryunosuke; Ikeda Hitoshi; Miyauchi Katsumi; Daida Hiroyuki; Aoki Junken; Yatomi Yutaka

来源：The Journal of Lipid Research, 2017, 58(2): 433-442.

DOI：10.1194/jlr.P071803

• acute coronary disease
• lysophosphatidic acids
• lysophosphatidylcholine
• lysophosphatidylethanolamine
• lysophosphatidylserine

Lysophosphatidic acids (LysoPAs) and lysophosphatidylserine (LysoPS) are emerging lipid mediators proposed to be involved in the pathogenesis of acute coronary syndrome (ACS). In this study, we attempted to elucidate how LysoPA and LysoPS become elevated in ACS using human blood samples collected simultaneously from culprit coronary arteries and peripheral arteries in ACS subjects. We found that: 1) the plasma LysoPA, LysoPS, and lysophosphatidylglycerol levels were not different, while the lysophosphatidylcholine (LysoPC), lysophosphatidylinositol, and lysophosphatidylethanolamine (LysoPE) levels were significantly lower in the culprit coronary arteries; 2) the serum autotaxin (ATX) level was lower and the serum phosphatidylserine-specific phospholipase A(1) (PS-PLA(1)) level was higher in the culprit coronary arteries; 3) the LysoPE and ATX levels were significant explanatory factors for the mainly elevated species of LysoPA, except for 22:6 LysoPA, in the peripheral arteries, while the LysoPC and LysoPE levels, but not the ATX level, were explanatory factors in the culprit coronary arteries; and 4) 18:0 and 18:1 LysoPS were significantly correlated with PS-PLA(1) only in the culprit coronary arteries. In conclusion, the origins of LysoPA and LysoPS might differ between culprit coronary arteries and peripheral arteries, and substrates for ATX, such as LysoPC and LysoPE, might be important for the generation of LysoPA in ACS.

• 出版日期2017-2