A new and efficient strategy for the synthesis of podophyllotoxin and its analogues

作者：Wu Yingming^*; Zhang Hongbin; Zhao Yuanhong; Zhao Jingfeng; Chen Jingbo; Li Liang

来源：Organic Letters, 2007, 9(7): 1199-1202.

DOI：10.1021/ol0630954

An efficient and stereoselective strategy for the total synthesis of podophyllotoxin was developed. This route leads to podophyllotoxin 1 in only 12 steps with 29% overall yield. A notable feature of this synthetic strategy is the use of the cascade addition-alkylation to ensure the key C1-C2 stereochemistry that is pivotal for the synthesis of podophyllotoxin.

• 出版日期2007-3-29
• 单位云南大学