Dose Escalation Study with Two Different Hypofractionated Intensity Modulated Radiotherapy Techniques for Localized Prostate Cancer: Acute Toxicity

作者：Zilli Thomas^*; Rouzaud Michel; Jorcano Sandra; Dipasquale Giovanna; Nouet Philippe; Ignacio Toscas Jose; Casanova Nathalie; Wang Hui; Escude Lluis; Molla Meritxell; Linero Dolors; Weber Damien C; Miralbell Raymond

来源：Technology in Cancer Research and Treatment, 2010, 9(3): 263-270.

• IMRT
• Prostate Cancer
• Hypofractionation
• Dose Escalation
• Acute Toxicity

To assess acute gastrointestinal (GI) and genitourinary (GU) toxicities in patients with localized prostate cancer treated with a sequential dose escalation hypofractionated intensity-modulated radiotherapy (IMRT) study using two different delivery methods Since 2003, 88 and 48 patients were sequentially treated to 56 Gy and to 60 Gy (4 Gy/fraction twice weekly), respectively IMRT with 6 MV beams was delivered with five fields in Geneva and with nine in Barcelona Acute Cl and GU side effects were scored weekly during treatment and 6 weeks after treatment completion using the Radiation Therapy Oncology Group (RTOG) toxicity scale Clinical, technical, and dosimetric parameters were analyzed in order to assess for a potential correlation with toxicity
Grade 1-2, GU and GI toxicities during and 6 weeks after treatment completion were 64%, and 24%, and 35% and 12%, respectively Only one Grade 4 GU toxicity, consisting of transitory urinary obstruction, was observed Patients treated to 60 Gy in Geneva presented a higher rate of Grade 1-2 GU toxicity (p = 001), while patients treated to both 56 and 60 Gy in Barcelona presented a higher Grade 1-2 GI toxicity (p = 0 02) A lower rate of rectal toxicity was observed in the subgroup of 22 patients treated with a rectal balloon (p = 0 02) The use of androgen deprivation therapy was associated with a higher rate of Grade 1-2 GU toxicity after the end of the treatment (p = 0 02) Dose escalation with either 14 x 4 Gy or 15 x 4 Gy delivered with two different IMRT techniques is feasible and is associated with a tolerable acute toxicity

• 出版日期2010-6