Microwave-Assisted Synthesis of GlycopolymerFunctionalized Silver Nanoclusters: Combining the Bioactivity of Sugar with the Fluorescence and Cytotoxicity of Silver

作者：Lu Wei; Ma Wenjuan; Lu Jiawei; Li Xiao; Zhao Yun^*; Chen Gaojian

来源：Macromolecular Rapid Communications, 2014, 35(8): 827-833.

DOI：10.1002/marc.201300905

• glycopolymers
• imaging
• microwave irradiation
• reversible addition fragmentation chain transfer (RAFT)
• silver nanoclusters

Copolymers of 2-(methacrylamido)glucopyranose (MAG) and methacrylic acid (MAA) are synthesized by RAFT polymerization and then used as templates to prepare glycopolymer-functionalized Ag nanoclusters (Gly-Ag NCs) through microwave irradiation. Polymers and the resulting nanoclusters are characterized by NMR, GPC, UV-Vis, SEM, TEM, AAS and fluorescence spectroscopy. The bio-activity of the fluorescent Gly-Ag NCs are further examined using GLUT-1 over-expressing cancer cells K562. Gly-Ag NCs show efficient binding ability toward K562 cells and inhibit the cell viability in a dose dependent manner (IC50 = 0.65 g mL(-1)), indicating their potential biological applications for both cancer imaging and targeted cancer therapy. <boxed-text content-type="graphic" position="anchor"> <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="urn:x-wiley:10221336:media:marc201300905:marc201300905-abs-0001">image</graphic

• 出版日期2014-4
• 单位苏州大学