Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae

作者：Tamma Pranita D^*; Huang Yanjie; Opene Belita N A; Simner Patricia J

来源：Antimicrobial Agents and Chemotherapy, 2016, 60(10): 6425-6429.

DOI：10.1128/AAC.00838-16

Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5 mu g/ml and meropenem, imipenem, and doripenem MICs of 2 mu g/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.

• 出版日期2016-10