Unusual clinical presentations of giant prolactinomas

作者：Grozinsky Gla**erg Simona; Shimon Ilan^*

来源：Pituitary, 2011, 14(4): 340-344.

DOI：10.1007/s11102-008-0160-0

• Giant prolactinomas
• Unusual symptoms
• Photophobia
• Mood changes
• CSF leak

Giant prolactinomas are rare pituitary tumors which have scarcely been reported in the literature. We describe three men with unusual presenting features of prolactin-secreting giant pituitary adenomas: prolonged and increasingly disturbing intolerance to light and noise; strange behavior and mood disturbances; and rhinorrhea followed by a finding of cerebrospinal fluid leakage. Treatment with dopamine agonist alleviated all symptoms, with concomitant suppression of plasma prolactin levels and a significant reduction in tumor mass. These cases emphasize the importance of considering unusual symptoms in the differential diagnosis of giant prolactinomas and the effectiveness of medical treatment.

• 出版日期2011-12