Prolonged viremia in dengue virus infection in hematopoietic stem cell transplant recipients and patients with hematological malignancies

作者：de Souza Pereira Barbara Brito; Darrigo Junior Luiz Guilherme; de Mello Costa Thalita Cristina; Felix Alvina Clara; Simoes Belinda P; Stracieri Ana Beatriz; da Silva Paula Moreira; Mauad Marcos; Machado Clarisse M

来源：Transplant Infectious Disease, 2017, 19(4): e12721.

DOI：10.1111/tid.12721

• dengue virus
• hematological malignancies
• HSCT
• immunocompromised patients
• prolonged viremia

Fever, skin rash, headache, and thrombocytopenia are considered hallmarks of dengue infection. However, these symptoms are frequently observed in infectious and non-infectious complications of hematopoietic stem cell transplant recipients and oncohematological patients. Thus, laboratory confirmation of dengue is relevant for prompt intervention and proper management of dengue in endemic and non-endemic regions. Because no prospective study of dengue has been conducted in these populations, the actual morbidity and mortality of dengue is unknown. In the present series, we describe five cases of dengue in patients living in endemic areas, emphasizing the prolonged course of the disease and the occurrence of prolonged viremia.

• 出版日期2017-8