摘要
BRUNING, R. S., J. D. DAHMUS, W. L. KENNEY, AND L. M. ALEXANDER. Aspirin and Clopidogrel Alter Core Temperature and Skin Blood Flow during Heat Stress. Med. Sci. Sports Exerc., Vol. 45, No. 4, pp. 674-682, 2013. Antithrombotic therapy with oral aspirin (ASA) or clopidogrel (CLO) (Plavix (R); Bristol-Myers Squibb, Bridgewater, NJ) is associated with an attenuated skin vasodilator response and a greater rate of rise in core temperature in healthy, middle-age individuals during passive heating in a water perfused suit. Purpose: The present double-blind, crossover study examined the functional consequences of 7 d of low-dose ASA (81 mg.d(-1)) versus CLO (75 mg.d(-1)) treatment in 14 healthy, middle-age (50-65 yr) men and women during passive heating in air (40 min at 30 degrees C, 40% relative humidity) followed by exercise (60% (V) over dotO(2peak)). Methods: Oral temperature (T-or) was measured in the antechamber (23.0 degrees C +/- 0.1 degrees C) before entering a warm environmental chamber. After 40 min of rest, subjects cycled on a recumbent cycle ergometer for up to 120 min. Esophageal temperature (T-es) and laser Doppler flux were measured continuously, and the latter was normalized to maximal cutaneous vascular conductance (% CVCmax). Results: Before entry into the environmental chamber there were no differences in T-or among treatments; however, after 40 min of rest in the heat, T-es was significantly higher for ASA and CLO versus placebo (37.2 degrees C +/- 0.1 degrees C, 37.3 degrees C +/- 0.1 degrees C, vs 37.0 degrees C +/- 0.1 degrees C, both P < 0.001), a difference that persisted throughout exercise (P < 0.001 vs placebo). The mean body temperature thresholds for the onset of cutaneous vasodilation were shifted to the right for both ASA and CLO during exercise (P < 0.05). Conclusion: ASA and CLO resulted in elevated core temperatures during passive heat stress and shifted the onset of peripheral thermoeffector mechanisms toward higher body temperatures during exercise heat stress.
- 出版日期2013-4