科研之友
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摘要
A highly enantioselective Michael addition of -ketoesters to enones was achieved by using the salt of a readily available primary -amino acid as the catalyst. The obtained Michael adducts were converted into enantioenriched 1,5-diketones in high yields through a common decarboxylation reaction under acidic conditions. A plausible reaction mechanism for the Michael addition reaction, which is supported by results of mechanistic studies that include DFT calculations, is also described.
- 出版日期2014-4
