Diet Enriched with Korean Pine Nut Oil Improves Mitochondrial Oxidative Metabolism in Skeletal Muscle and Brown Adipose Tissue in Diet-Induced Obesity

作者：Ngoc Hoan Le; Shin Sunhye; Thai Hien Tu; Kim Chu Sook; Kang Ji Hye; Tsuyoshi Goto; Teruo Kawada; Han Sung Nim; Yu Rina^*

来源：Journal of Agricultural and Food Chemistry, 2012, 60(48): 11935-11941.

DOI：10.1021/jf303548k

• Obesity
• pine nut oil
• oxidative metabolism
• skeletal muscle
• brown adipose tissue

In this study, we investigated effects of pine nut oil (PNO) on high-fat-diet (HFD)-induced obesity and metabolic dysfunction in skeletal muscle and brown adipose tissue (BAT). Male C57BL/6 mice were fed a HFD with 15% energy from lard and 30% energy from either soybean oil (SBO-HFD) or PNO (PNO-HFD) for 12 weeks. The PNO-HFD resulted in less weight gain and intramuscular lipid accumulation than the SBO-HFD and was accompanied by upregulation of transcripts and proteins related to oxidative metabolism and phosphorylation of AMP-activated protein kinase (AMPK), as well as molecules selectively expressed in type I and type IIa muscle fibers. In addition, uncoupling protein-1 was upregulated in BAT. These beneficial metabolic effects were partly associated with the dual ligand activity of pinolenic acid, which is abundant in PNO, for peroxisome proliferator-activated receptors alpha and delta. Our findings suggest that PNO may have potential as a dietary supplement for counteracting obesity and metabolic dysregulation.

• 出版日期2012-12-5