科研之友
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摘要
A straightforward access to 5,6-dihydropyrimidin-4-ones as racemic mixtures or enantiopure diastereoisomers was achieved thanks to a multicomponent Knoevenagel-aza-Michael-Cyclocondensation reaction involving Meldrum's acid and isourea derivatives. This constitutes not only a novel MCR of the original Biginelli-Atwal condensation but allows the construction of dihydrouracyl derivatives known as biorelevant diazole architectures.
- 出版日期2015
