Development of Swellable Local Implants of a Polyethyleneimine-Poly(Vinyl Pyrrolidone) (PEI-PVP) Hydrogel as a Socket Filler

作者：Chang Ching Wen; Ho Hsiu O; Lo Yi June; Lee Sheng Yang; Yang You Ren; Sheu Ming Thau^*

来源：Journal of Biomaterials Science, Polymer Edition, 2012, 23(17): 2171-2184.

DOI：10.1163/092050611X611684

• Polyethyleneimine
• poly(vinyl pyrrolidone)
• socket filler
• hydrogel

In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) crosslinked with various concentrations (0, 0.125, 0.25 and 0.5%) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cytotoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI-PVP hydrogels were examined in male beagles and compared to values using Spongostan (R). Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI-PVP hydrogels or Spongostan (R). In the in vivo study, PEI-PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan (R). In conclusion, PEI-PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI-PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.

• 出版日期2012