A and B Blood Group Antigens in Human Pancreatic Ductal Adenocarcinomas

作者：Handra Luca Adriana^*

来源：Oncology, 2013, 84(3): 141-149.

DOI：10.1159/000345028

• Pancreas
• Adenocarcinoma
• Blood group
• Prognosis

Objectives:The aim of this study was to determine the clinicopathological significance of blood group expression patterns in patients with surgically resected pancreatic ductal adenocarcinomas. Methods: Pancreatic ductal adenocarcinomas from 459 patients were analyzed for immunohistochemical expression of A and B blood group antigens on tissue nnicroarrays. Correlations were established by Fisher%26apos;s test, chi(2) test, and logistic regression models, and relationships to postsurgical overall survival were analyzed by Kaplan-Meier method, log-rank test, and multivariate Cox models. Results: Tumors expressing blood group A antigen predicted fewer lymph node metastases (%26lt;3) and had longer postoperative survival by univariate and multivariate analysis. Loss of A antigen tumor expression in A blood group type patients correlated to vascular invasion. Conclusion: In patients with resectable pancreatic ductal adenocarcinomas, blood group A antigen expression predicted fewer lymph node metastases and was associated with improved outcome after pancreaticoduodenectomy.

• 出版日期2013