Amyloid-beta oligomers as a template for secondary amyloidosis in Alzheimer%26apos;s disease

作者：Guerrero Munoz Marcos J^*; Castillo Carranza Diana L; Krishnamurthy Shashirekha; Paulucci Holthauzen Adriana A; Sengupta Urmi; Lasagna Reeves Cristian A; Ahmad Yembur; Jackson George R; Kayed Rakez

来源：Neurobiology of Disease, 2014, 71: 14-23.

DOI：10.1016/j.nbd.2014.08.008

• Protein aggregation
• Alzheimer%26apos
• s disease
• Mixed proteinopathy
• A beta oligomers and cross seeding

Alzheimer%26apos;s disease is a complex disease characterized by overlapping phenotypes with different neurodegenerative disorders. Oligomers are considered the most toxic species in amyloid pathologies. We examined human AD brain samples using an anti-oligomer antibody generated in our laboratory and detected potential hybrid oligomers composed of amyloid-beta, prion protein, alpha-synuclein, and TDP-43 phosphorylated at serines 409 and 410. These data and in vitro results suggest that A beta oligomer seeds act as a template for the aggregation of other proteins and generate an overlapping phenotype with other neuronal disorders. Furthermore, these results could explain why anti-amyloid-beta therapy has been unsuccessful.

• 出版日期2014-11