A Study of Antibacterial Activity of Some Novel 8-Methoxy-4-methyl-quinoline Derivatives

作者：Singh Sheoraj; Kumar Vikas; Kumar Ashok; Sharma Shalabh^*; Dua Piyush

来源：Bulletin of the Korean Chemical Society, 2010, 31(12): 3605-3610.

DOI：10.5012/bkcs.2010.31.12.3605

• Quinoline
• Schiff base
• Azetidinone
• Thiazolidinone
• Antibacterial activity

In the present study, some quinoline derivatives have been synthesized like 8-methoxy-4-methyl-2-amino-(3'-chloro-2'-oxo-4'-substituted aryl-1'-azetidinyl)quinolines 8-12 and 8-methoxy-4-methyl-2-amino-(2'-substituted aryl-4'-oxo-1',3'-thiazolidin-3'-yl) quinolines 13-17 from 8-methoxy-4-methyl-2-(substituted arylidenyliminoamino)-quinolines 3-7. The structural assignments of these compounds were based on spectral (IR,(1)H-NMR, Mass) and elemental (C, H, N) analysis. Further, these compounds were evaluated for antibacterial activity against various bacterial strains. Three compounds 10, 11 and 16 were found to exhibit potent antibacterial activity as compared to the standard drug amphicillin.

• 出版日期2010-12-20