Assessing the role of the medial preoptic area in ethanol-induced hypothermia

作者：Westerman Ashley T; Roma Peter G; Price Rebecca C; Dominguez Juan M^*

来源：Neuroscience Letters, 2010, 475(1): 25-28.

DOI：10.1016/j.neulet.2010.03.034

• Ethanol
• Hypothermia
• Fos
• Preoptic area

Administration of ethanol produces hypothermia. The preoptic area/anterior hypothalamus (POA/AH) contains warm- and cold-sensitive neurons that are important for temperature regulation. The present study evaluated the effect of ethanol on Fos immunoreactivity (Fos-ir) in the medial preoptic area (MPOA) and the effect of lesions to the MPOA on ethanol-induced hypothermia. Rats receiving 1.5-g/kg ethanol showed an increase in Fos-ir in the MPOA. However, lesions to the MPOA did not affect core body temperature. These findings indicate that ethanol increases neural activity in the MPOA, but this increased activity does not influence ethanol-induced changes in core body temperature.

• 出版日期2010-5-7