Dietary Supplementation of Curcumin Alleviates NF-κB-dependent Skeletal Muscle Wasting in Rat

作者：He, Jun^*; Xie, Hongmei; Wu, Shan

来源：Endocrine, Metabolic and Immune Disorders - Drug Targets, 2016, 16(2): 140-147.

DOI：10.2174/1871530316666160613115221

• Curcumin
• inflammation
• muscle wasting
• nutrition
• regulation
• rat

Background: Activation of the nuclear factor-kappa beta (NF-kappa B) signaling results in releasing of a variety of inflammatory cytokines that can induce skeletal muscle wasting (MW) in mammals. Curcumin is a natural product from spice turmeric that can block biological events in which NF-kappa B plays a critical role. @@@ Objective: The present study was conducted to evaluate the beneficial effects of curcumin on the NF-kappa B-dependent MW in rats. @@@ Methods: The MW rats were induced by lipopolysaccharide (LPS) injection and rats were fed 15 g curcumin per kg diet for 16 d. @@@ Results: LPS not only decreased the growth performance of rat, but significantly elevated its serum IL-1 concentration and muscle proteolysis rate. Interestingly, curcumin significantly prevented the muscle proteolysis rate and down-regulated expression levels of two critical muscle-specific ubiquitin ligases (Atrogin-1 and MuRF-1). When muscles from MW rats were incubated with curcumin in vitro, the calpain-, cathepsin L-, and proteasome-dependent muscle proteolysis were significantly decreased. Moreover, the nuclear NF-kappa B/p65 protein abundance were also decreased by curcumin. @@@ Conclusion: The results not only suggest a molecular mechanism by which curcumin modulates the inflammatory responses, but also offer a feasible avenue to ameliorate the NF-kappa B-dependent muscle proteolysis.

• 出版日期2016
• 单位四川农业大学