A Ru(II) complex with 2-(4-(methylsulfonyl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthrolin e: Synthesis, characterization, and acid-base and DNA-binding properties

作者：Gao, Jie; Wang, Zhi-Ping; Yuan, Cui-Li; Jia, Hai-Shun; Wang, Ke-Zhi^*

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2011, 79(5): 1815-1822.

DOI：10.1016/j.saa.2011.05.063

• Ruthenium
• DNA
• Spectroscopy

A new Ru(II) complex of [Ru(bpy)(2)(Hmspip)]Cl-2 (in which bpy=2,2'-bipyridine, Hmspip=2-(4-(methylsulfonyl)phenyl)-1H-imidazo[4.5-f][1,10]phenanthroline} have been synthesized and characterized. The ground- and excited-state acid-base properties of [Ru(bpy)(2)(Hmspip)Cl-2 and its parent complex of [Ru(bpy)(2)(Hpip)]Cl-2 {Hpip=2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline} have been studied by UV-visible (UV-vis) and emission spectrophotometric pH titrations. [Ru(bpy)(2)(Hmspip)Cl-2 acts as a calf thymus DNA intercalators with a binding constant of 4.0 x 10(5) M-1 in buffered 50 mM NaCl, as evidenced by UV-vis and luminescence titrations, steady-state emission quenching by [Fe(CN)(6)](4-), DNA competitive binding with ethidium bromide, reverse salt titrations and viscosity measurements.

• 出版日期2011-9
• 单位集宁师范学院; 北京师范大学