Sythesis of Partially N-Acetylated Chitooligosaccharides and Muropeptides

作者：Bedini Emiliano^*; Cirillo Luigi; Marchetti Roberta; Basso Sara; Tufano Diego; Molinaro Antonio; Parrilli Michelangelo

来源：Synlett, 2014, 25(3): 365-370.

DOI：10.1055/s-0033-1340323

• bioorganic chemistry
• oligosaccharides
• glycopeptides
• glycosylation
• chitosan
• peptidoglycan

Partially N-acetylated chitooligosaccharides and muropeptides are referred to as microbial associated molecular patterns (MAMPs). To shed light on the molecular basis of their recognition by the innate immunity system of living organisms, their production in pure form is necessary. To this end, we present here the first synthetic strategy for the obtainment of a series of partially N-acetylated muropeptides as well as of a chitodisaccharide and a chitotetrasaccharide, all possessing a well-defined N-acetylation pattern.

• 出版日期2014-2-13