Age at Last Birth in Relation to Risk of Endometrial Cancer: Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium

作者：Setiawan Veronica Wendy^*; Pike Malcolm C; Karageorgi Stalo; Deming Sandra L; Anderson Kristin; Bernstein Leslie; Brinton Louise A; Cai Hui; Cerhan James R; Cozen Wendy; Chen Chu; Doherty Jennifer; Freudenheim Jo L; Goodman Marc T; Hankinson Susan E; Lacey James V Jr; Liang Xiaolin; Lissowska Jolanta; Lu Lingeng; Lurie Galina; Mack Thomas; Matsuno Rayna K; McCann Susan; Moysich Kirsten B; Olson Sara H; Rastogi Radhai; Rebbeck Timothy R; Risch Harvey

来源：American Journal of Epidemiology, 2012, 176(4): 269-278.

DOI：10.1093/aje/kws129

• endometrial neoplasms
• parity
• reproductive history

Childbearing at an older age has been associated with a lower risk of endometrial cancer, but whether the association is independent of the number of births or other factors remains unclear. Individual-level data from 4 cohort and 13 case-control studies in the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 8,671 cases of endometrial cancer and 16,562 controls were included in the analysis. After adjustment for known risk factors, endometrial cancer risk declined with increasing age at last birth (P-trend 0.0001). The pooled odds ratio per 5-year increase in age at last birth was 0.87 (95 confidence interval: 0.85, 0.90). Women who last gave birth at 40 years of age or older had a 44 decreased risk compared with women who had their last birth under the age of 25 years (95 confidence interval: 47, 66). The protective association was similar across the different age-at-diagnosis groups and for the 2 major tumor histologic subtypes (type I and type II). No effect modification was observed by body mass index, parity, or exogenous hormone use. In this large pooled analysis, late age at last birth was independently associated with a reduced risk of endometrial cancer, and the reduced risk persisted for many years.

• 出版日期2012-8-15
• 单位上海市肿瘤研究所; 河北医科大学