A novel indeno[1,2-b] pyridinone derivative, a DNA intercalative human topoisomerase II alpha catalytic inhibitor, for caspase 3-independent anticancer activity

作者：Jeon K H; Park C; Kadayat T M; Shrestha A; Lee E S; Kwon Y

来源：Chemical Communications, 2017, 53(51): 6864-6867.

DOI：10.1039/c7cc02372c

A novel 2-(furan-2-yl)-4-(pyridin-2-yl)-5H-indeno[1,2-b] pyridin-5-one (TI-1-190) was synthesized using a simple microwave-assisted method and its mode of action was systematically characterized. It is a DNA intercalative human topoisomerase II alpha catalytic inhibitor with much stronger activity and less DNA toxicity than etoposide, a topoisomerase II poison. TI-1-190 displays caspase 3-independent anticancer activity, unlike etoposide.

• 出版日期2017-6-28