The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line

作者：Takata Minoru^*; Ishiai Masamichi; Kitao Hiroyuki

来源：Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2009, 668(1-2): 92-102.

DOI：10.1016/j.mrfmmm.2008.12.012

• Fanconi anemia
• Interstrand crosslink
• DNA repair
• Translesion synthesis
• Homologous recombination
• DT40 cell line

The Fanconi anemia (FA) pathway is a complex phosphorylation-ubiquitination network in the DNA damage signaling, which is still poorly understood. Defects in the "FA pathway" or in the related DNA repair proteins cause FA, a hereditary disorder that accompanies compromised DNA crosslink repair, poor hematopoetic stem cell survival, genomic instability, and cancer. For molecular dissection of the FA pathway, we have been using chicken B cell line DT40 as a model system. In this review, we will summarize our current understanding of the pathway, and discuss how studies using DT40 have contributed to this rapidly evolving field.

• 出版日期2009-7-31