Dual-mode laparoscopic fluorescence image-guided surgery using a single camera

作者：Gray Daniel C^*; Kim Evgenia M; Cotero Victoria E; Bajaj Anshika; Staudinger V Paul; Hehir Cristina A Tan; Yazdanfar Siavash

来源：Biomedical Optics Express, 2012, 3(8): 1880-1890.

Iatrogenic nerve damage is a leading cause of morbidity associated with many common surgical procedures. Complications arising from these injuries may result in loss of function and/or sensation, muscle atrophy, and chronic neuropathy. Fluorescence image-guided surgery offers a potential solution for avoiding intraoperative nerve damage by highlighting nerves that are otherwise difficult to visualize. In this work we present the development of a single camera, dual-mode laparoscope that provides near simultaneous display of white-light and fluorescence images of nerves. The capability of the instrumentation is demonstrated through imaging several types of in situ rat nerves via a nerve specific contrast agent. Full color white light and high brightness fluorescence images and video of nerves as small as 100 mu m in diameter are presented.

• 出版日期2012-8-1