Age-dependent effects on sensory axonal excitability in normal mice

作者：Banzrai Chimeglkham; Nodera Hiroyuki^*; Higashi Saki; Okada Ryo; Osaki Yusuke; Mori Atsuko; Kaji Ryuji

来源：Neuroscience Letters, 2016, 611: 81-87.

DOI：10.1016/j.neulet.2015.11.032

• Axonal excitability
• Age-related change
• Sensory nerve
• Ion conductance

Serial recordings were performed to measure sensory excitability in peripheral nerves and elucidate age-dependent changes in neuronal ion currents in the peripheral sensory nervous system. The threshold tracking technique was used to measure multiple excitability indices in the tail sensory nerves of five normal male mice at four time points (6, 10, 14, and 19 weeks of age). A separate group of four mice was also measured at 43 weeks and at 60 weeks of age. Maturation was accompanied by an increase in early hyperpolarization and superexcitability at 10 weeks. At 60 weeks, the hyperpolarizing electrotonus shifted downward, while superexcitability became greater and subexcitability (double stimuli) decreased. Computer modeling showed that the most notable age-related interval changes in excitability parameters were Barrett Barrett, H, and slow K+ conductances. Understanding age-related changes in the excitability of sensory axons may provide a platform for understanding age-dependent sensory symptoms and developing age-specific channel-targeting therapies.

• 出版日期2016-1-12