An environmentally benign catalytic oxidation of cholesteryl acetate with molecular oxygen by using N-hydroxyphthalimide

作者：Yao Zhen; Hu Xingbang; Mao Jianyong; Li Haoran^*

来源：Green Chemistry, 2009, 11(12): 2013-2017.

DOI：10.1039/b915737a

A green and effective method is reported for the oxidation of cholesteryl acetate to 7-keto-cholesteryl acetate with O(2) in the presence of catalytic amounts of N-hydroxyphthalimide (NHPI) under mild conditions. It was found that Co(OAc)(2) could cooperate with Mn(OAc)(2) to enhance the catalytic ability of NHPI resulting in better yields. This economical and environmentally-friendly method provides a potentially new way for the synthesis of the intermediate product of vitamin D(3) in industry, which eliminates the use of large amounts of bromine in present route and overcomes the drawbacks of the known oxidation methods.

• 出版日期2009
• 单位浙江大学