Alpinetin/hydroxypropyl-beta-cyclodextrin host-guest system: Preparation, characterization, inclusion mode, solubilization and stability

作者：Ma Shui Xian; Chen Wen; Yang Xiao Dong^*; Zhang Na; Wang Shao Jie; Liu Lin; Yang Li Juan

来源：Journal of Pharmaceutical and Biomedical Analysis, 2012, 67-68: 193-200.

DOI：10.1016/j.jpba.2012.04.038

• Alpinetin
• Hydroxypropyl-beta-cyclodextrin
• Inclusion complex
• Solubilization
• Stability

The inclusion complexation behavior, characterization and binding ability of alpinetin with hydroxypropyl-beta-cyclodextrin (HP beta CD) has been investigated in both solution and the solid state by means of UV-vis spectroscopy, FT-IR, H-1 and 2D NMR, XRD, SEM and DSC. The results showed that the water solubility and stability of alpinetin were obviously increased in the inclusion complex with HP beta CD. This satisfactory water solubility and high stability of the alpinetin/HP beta CD complex will be potentially useful for its application as herbal medicine or healthcare products.

• 出版日期2012-9
• 单位云南大学