Asymmetric conduction in biological nanopores created by high-intensity, nanosecond pulsing: Inference on internal charge lining the membrane based on a model study

作者：Joshi R P^*; Qiu H

来源：Journal of Applied Physics, 2015, 118(9): 094701.

DOI：10.1063/1.4929808

Nanosecond, high-intensity electric pulses have been reported to open rectifying pores in biological cell membranes. The present goal is to qualitatively understand and analyze the experimental current-voltage (I-V) data. Here, nanopore transport is probed using a numerical method and on the basis of an analytical model. Our results show that geometric asymmetry in the nanopore would not yield asymmetry in the I-V characteristics. However, positive surface charge lining the pore could produce characteristics that compare well with data from patch-clamp measurements, and a value of similar to 0.02 C/m(2) is predicted from the numerical calculations.

• 出版日期2015-9-7