Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution

作者:Hong, Xiao-Wei; Zhou, Yu-Qiang; Bai, Cui-Bing; Wang, Nai-Xing*; Xing, Yalan; Zhang, Wei; Wang, Yan-Jing; Lan, Xing-Wang; Xie, Yu; Li, Yi-He
来源:Molecules, 2015, 20(9): 17208-17220.
DOI:10.3390/molecules200917208

摘要

An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed.