A facile method to enable a model phospholipid cell-permeable and photoactivatable

作者：Singh Manish K; Waybright Jarod; Zhang Qisheng^*

来源：Tetrahedron, 2017, 73(26): 3677-3683.

DOI：10.1016/j.tet.2017.04.026

• Phospholipids
• Cell-permeable
• Photoactivatable
• Cell signaling
• Photocage

Directly utilizing phospholipids in cellular studies is limited by their dynamic metabolism and lack of cell permeability. We have developed a facile method to enable a fluorescent model phospholipid cell permeable and photoactivatable. This method features the reaction of a diazo-containing molecule with either phosphonic or phosphoric acids to form the corresponding photocaged esters under mild conditions, and should be generally applicable to endogenous phospholipids.

• 出版日期2017-6-29