Asymptomatic Infection with Visceral Leishmaniasis in a Disease-Endemic Area in Bihar, India

作者：Topno Roshan K^*; Das Vidya N R; Ranjan Alok; Pandey Krishna; Singh Dharmender; Kumar Nawin; Siddiqui Niyamat A; Singh Vijay P; Kesari Shreekant; Kumar Narendra; Bimal Sanjeev; Kumar Annadurai Jeya; Meena Chetram; Kumar Ranjeet; Das Pradeep

来源：The American Journal of Tropical Medicine and Hygiene, 2010, 83(3): 502-506.

DOI：10.4269/ajtmh.2010.09-0345

A prospective study was carried out in a cohort of 355 persons in a leishmaniasis-endemic village of the Patna District in Bihar. India. to determine the prevalence of asymptomatic persons and rate of progression to symptomatic visceral leishmaniasis (VL) cases At baseline screening. 50 persons were positive for leishmaniasis by any of the three tests (rK39 strip test, direct agglutination test, and polymerase chain reaction) used. Point prevalence of asymptomatic VL was 110 per 1.000 persons and the rate of progression to symptomatic cases was 17 85 per 1,000 person-months The incidence rate ratio of progression to symptomatic case was 3 36 (95% confidence interval [CI] = 0 75-15 01, P = 0 09) among case-contacts of VL compared with neighbors. High prevalence of asymptomatic persons and clinical VL cases and high density of Phlebotomus argentipes sand flies can lead to transmission of VL in VL-endemic areas

• 出版日期2010-9
• 单位河北医科大学