Comparative protection of two different commercial vaccines against Yersinia ruckeri serotype O1 and biotype 2 in rainbow trout (Oncorhynchus mykiss)

作者：Deshmukh S^*; Raida M K; Dalsgaard I; Chettri J K; Kania P W; Buchmann K

来源：Veterinary Immunology and Immunopathology, 2012, 145(1-2): 379-385.

DOI：10.1016/j.vetimm.2011.12.014

• Rainbow trout
• Yersinia ruckeri serotype O1, biotype 2
• Vaccine
• RPS
• Pathology

Differentially extended specific protection by two commercial vaccines against Yersinia ruckeri serotype O1 biotype 2 was studied following 30 s immersion exposure. Rainbow trout were challenged intra-peritoneally (i.p.) with Y. ruckeri serotype O1, biotype 2 (approximate to 10(6) to 10(7) CFU/fish) at 4, 6 and 8 months after vaccination with vaccines containing either biotype 1 (AquaVac (R) ERM) or both biotypes 1 and 2 (AquaVac (R) RELERA (TM)). The specific pattern of vaccine-mediated protection was evaluated by relative percentage survival (RPS) analysis at 4 and 6 months post-vaccination and by obtaining gross pathological observations at 4 and 8 months respectively. We determined specific significant and superior protection in terms of increased survivability in AquaVac (R) RELERA (TM) vaccinated fish and observed correspondingly fewer pathological changes. The challenge trials indicated a longer protection for at least 6 months without any booster vaccination. A specific and adaptive response induced by AquaVac (R) RELERA (TM) vaccine against Y. ruckeri biotype 2 was clearly indicated. In addition, some degree of cross protection rendered by AquaVac (R) ERM containing biotype 1 during infection with Y. ruckeri biotype 2 was also noted.

• 出版日期2012-1-15